Sophia Yancopoulos
RESEARCH | CV |
- A physicist moving towards biology.
- I worked on the
role of internal water in transmembrane proteins with
Dr. Mihaly Mezei and Dr. Roman Osman at the Icahn School of Medicine at Mount Sinai
- At U Penn's Center of Bioinformatics
I worked on signal peptides with Dr. Artemis Hatzigeorgiou.
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WHERE I WORKED
The New York Genome Center (NYGC) is an independent research organization based on the notion that scientific discovery in genomic science will increase by using a multi- institutional and multi-disciplinary approach.
NYGC's expertise is in whole genome sequencing, genomic analysis, computational biology, and the discovery of novel biomedical models.
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Experimental Immunology
Nicholas
Chiorazz, MD leads an internationally recognized research
program on chronic lymphocytic leukemia (CLL), the most common
Western adult leukemia, with almost 10,000 new cases in 2006 in the US alone.
A goal of the research is to define antigens recognized by CLL cells.
This will help scientists understand causes of the disease and to develop
treatments.
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RESEARCH
A while back, I taught a course in bioinformatics
with an associated lecture series which led to my
developing an interest in genome evolution.
I then worked on a novel model of genome rearrangements
in evolution. In Dr. Chiorazzi's lab, I explored the connections
between evolution, cancer and the adaptive immune system including the
implications for what happens when our immune systems go awry, possibly
leading to leukemia.
Papers:
1. Damle N, Temburni S, Calissano C, Yancopoulos
S, Banapur T, Sison C, Allen SL, Rai KR, Chiorazzi N. CD38 expression labels an activated subset within chronic
lymphocytic leukemia clones enriched in proliferating B cells. Blood. 2007 August epub
2. Yan XJ, Albesiano E, Zanesi N, Yancopoulos
S, Sawyer A, Romano E, Petlickovski A, Efremov DG, Croce CM, Chiorazzi N.
B
cell receptors in TCL1 transgenic mice resemble those of aggressive, treatment-resistant
human chronic lymphocytic leukemia.Proc Natl Acad Sci U S A. 2006
Aug 1;103(31):11713-8.
3. Yancopoulos S, Attie O, Friedberg R. Efficient
sorting of genomic permutations by translocation, inversion and block interchange.
Bioinformatics. 2005 Aug 15;21(16):3340-6.
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