RESEARCH | CV |
WHERE I WORK
Institute for Medical Research has hundreds of scientists working
on a wide range of medical conditions such as autoimmunity, arthritis,
cancer, lymphoma, sepsis, and a host of neurological disorders.
We recently built state of the art new research facility.
Chiorazz, MD leads an internationally recognized research program
on chronic lymphocytic leukemia (CLL), the most common Western
adult leukemia, with almost 10,000 new cases in 2006 in the US alone. A
current goal of the program is to define antigens recognized by CLL cells.
This will help scientists understand causes of the disease and to develop
A while back, I taught a course in bioinformatics
with an associated lecture series which led to my
developing an interest in genome evolution.
I've worked on a novel model of genome rearrangements
in evolution. In Dr. Chiorazzi's lab, I explore the connections
between evolution, cancer and the adaptive immune system including the
implications for what happens when our immune systems go awry possibly
leading to leukemia.
1. Damle N, Temburni S, Calissano C, Yancopoulos
S, Banapur T, Sison C, Allen SL, Rai KR, Chiorazzi N. CD38 expression labels an activated subset within chronic
lymphocytic leukemia clones enriched in proliferating B cells. Blood. 2007 August epub
2. Yan XJ, Albesiano E, Zanesi N, Yancopoulos
S, Sawyer A, Romano E, Petlickovski A, Efremov DG, Croce CM, Chiorazzi
N. B cell receptors
in TCL1 transgenic mice resemble those of aggressive, treatment-resistant
human chronic lymphocytic leukemia.Proc Natl Acad Sci U S A. 2006
3. Yancopoulos S, Attie O, Friedberg R. Efficient
sorting of genomic permutations by translocation, inversion and block
Bioinformatics. 2005 Aug 15;21(16):3340-6.